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= Link to open-access journal article

The key formulation caveat is timing and separation

In senescent cells, the transcription factor FOXO4 binds to p53 (the tumor suppressor "guardian of the genome"), sequestering p53 away from mitochondria where it would trigger apoptosis

However, both have been compared to semaglutide and placebo in separate trials, allowing indirect comparisons

Common regimens include 50 mg/kg intraperitoneally twice daily for 1228 days in C57BL/6J or ob/ob mice, with indirect calorimetry and body-composition endpoints